Itraconazole 

Pharmaceutical Group: Antifungal 

Therapeutic indications:Treatment of fungal infection of the vagina, skin, mouth, eyes, nails and internal organs

Dosage Form(s):  Capsule
Pregnancy Category: C

The Itragin capsule contains the active ingredient Itraconazole, which belongs to the antifungal medicine group. Itragein capsules are indicated for the treatment of fungal infection of the vagina, skin, mouth, eyes, nails and internal organs.

Indications

Itragein capsules are indicated for treatment of fungal infections  in adults and in the following cases:
• Fungal infection of the mouth, vagina, skin, eyes, nails and internal organs.
• Fungal infections that damage other parts of the body.

Presentation 

30 Capsules

Dosage and direction

• Vaginal infections: 2 capsules in the morning and 2 capsules after 12 hours ,one day
• Infections of the mouth: 1 capsule once a day,15 days
• Skin infections

The dose depends on the severity of the infection. Your doctor may prescribe one of the  following doses: 2 capsule once a day for 7 days, or 1 capsule per day for 15 days or 1 capsule once a day for one month.

• Infections of other organs

Depending on the severity of the infection, the doctor tells you exactly what dose to take . 

Itragin capsule should be taken immediately following a meal for maximum absorption. Capsules must be swallowed whole with a small amount of water.

Contraindications

Allergic to itraconazole or any of the other ingredients of this medicine-

Pregnancy, or decided to be pregnant, unless the doctor has told to take-

Special warning and precaution

Talk to your doctor or pharmacist before taking Itraconazole capsules if:
• you have ever had kidney problems. Your dose of itraconazole capsules may have to be changed
• you have ever had liver problems such as yellow skin (jaundice). Your dose of itraconazole capsules may have to be changed.

If after taking this medicine you have a severe lack of appetite, feel sick (nausea), are sick (vomiting), feel unusually tired, get stomach pain, muscle weakness, yellowing of the skin or whites of the eyes, unusually dark urine, pale stools or hair loss, stop taking itraconazole capsules and tell your doctor straight away
• you have ever had a heart problem including heart failure, Itraconazole capsules could make it worse.

• You are infected with HIV virus or have immune deficiency
• Children and the elderly

Itraconazole capsules are not normally given to children or the elderly. However, doctor may prescribe them in special cases.

Blood tests
If your itraconazole capsules course is for more than one month, the doctor may want to check your liver by testing your blood

Other medicines and Itraconazole capsules

• In particular, Itraconazole should not be taken with following drugs:

Terfenadine, Astemizole or Mizolastine , Atorvastatin, lovastatin or Simvastatin, Quinidine or Dofetilide, Bepridil and Nisoldipine, Eletriptan, Dihydroergotamine and Ergotamine, Cisapride ,Levacetylmethadol, Midazolam (by mouth) or Triazolam , Pimozide and Sertindole.

• Do not use itraconazole capsules within 2 weeks of taking these medicines.This medicine may stop itraconazole capsules from working properly:

Rifampicin, Rifabutin or Isoniazid, Phenytoin, Carbamazepine or Phenobarbital, St. John’s Wort

• Tell your doctor before taking, or if you are already taking any of the following medicines. They may need to alter the dose of itraconazole capsules or your other medicine:

Tranquillisers, Buspirone, Alprazolam or Brotizolam, Busulphan, Docetaxel, Trimetrexate, Warfarin, Ritonavir, Indinavir and Saquinivir, Clarithromycin or erythromycin, Digoxin and disopyramide, Cilostazol, Dihydropyridines and verapamil, Methylprednisolone, Fluticasone, Budesonide or dexamethasone, Ciclosporin, tacrolimus or rapamycin , Alfentanil and fentanyl, Ebastine, Halofantrine ,Reboxetine , Repaglinide , Midazolam

Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them. Stop using itraconazole capsules and tell your doctor straight away if you notice or suspect any of the following:
Sudden signs of allergy such as rash, hives , severe irritation of your skin, swelling of the face, lips, tongue or other parts of the body, Severe skin disorders with peeling and/ or rashes with small pustules (with a fever) or blistering of the skin, mouth, eyes and genitals, with fever, chills, aching muscles and generally feeling unwell. A tingling sensation, numbness or weakness in your limbs ,Severe lack of appetite, nausea, vomiting, unusual tiredness, stomach pain, muscle weakness, yellowing of your skin or whites of your eyes, unusually dark urine, pale stools or hair loss, Shortness of breath, unexpected weight gain, swelling of your legs or abdomen, feeling unusually tired or waking up short of breath at night.

 Pregnancy and breast-feeding

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.  Do not take itraconazole capsules if you are pregnant unless your doctor has told you to. 

Driving and using machines

Itraconazole capsules can sometimes cause dizziness, blurred/double vision or hearing loss. If you have these symptoms do not drive or use machines